FXR1 Antibody 3 Publications

Rabbit Polyclonal| Catalog number: 13194-1-AP

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Freight/Packing

Con: 53 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
mouse testis tissue, HEK-293 cells, HeLa cells, mouse heart tissue, mouse liver tissue, NIH/3T3 cells

Positive IP detected in:
mouse skeletal muscle tissue

Positive IHC detected in:
human kidney tissue, human heart tissue, human kidney tissue

Positive IF detected in:
Ethacrynic acid treated HepG2 cells, HepG2 cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:20-1:200
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
fragile X mental retardation, autosomal homolog 1

Calculated molecular weight:
621aa,70 kDa

Observed molecular weight:
60-80 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
FXR1

Synonyms
FXR1, hFXR1p
Background

Tumour necrosis factor-alpha (TNF-alpha) is a key mediator of inflammation in host defence against infection and in autoimmune disease. Its production is controlled post-transcriptionally by multiple RNA-binding proteins that interact with the TNF-alpha AU-rich element and regulate its expression; Fragile X mental retardation-related protein 1 (FXR1) is one of these. FXR1 (fragile-X-mental retardation-related protein 1) are RNA-binding proteins that have been demonstrated to impact miRNA-mediated, post-transcriptional gene regulation, and required for embryonic and postnatal development of muscle tissue. It can regulate intracellular transport and local translation of certain mRNAs


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