GALNS Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 14933-1-AP

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Con: 23 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
human liver tissue

Positive IHC detected in:
human kidney tissue

Recommended dilution:
WB : 1:200-1:1000
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
galactosamine (N-acetyl)-6-sulfate sulfatase

Calculated molecular weight:
58 kDa

Observed molecular weight:
50-55kd

GenBank accession number:

Gene ID (NCBI):

Gene symbol
GALNS

Synonyms
Chondroitinase, Chondroitinsulfatase, FLJ17434, FLJ42844, FLJ98217, Galactose 6 sulfate sulfatase, GALNAC6S, GalNAc6S sulfatase, GALNS, GAS, MPS4A
Background

GALNS(N-acetylgalactosamine-6-sulfatase) is also named as chondroitinase and belongs to the sulfatase family. It is one of sulfatases required to degrade glycosaminoglycans (GAGs), keratan sulfate (KS) and chondroitin-6-sulfate (C6S) and the enzyme is a dimer derived from two 60 kDa polypeptides, each of which is processed to 40 kDa and 15 kDa polypeptide subunits linked by disulfide bonds(PMID:15241807). The deduced 522-residue protein is composed of a 26-amino acid N-terminal signal peptide and a mature polypeptide of 496 amino acid residues, including 2 potential asparagine-linked glycosylation sites(PMID:1755850). Defects in GALNS are the cause of mucopolysaccharidosis type 4A (MPS4A), also known as Morquio A syndrome.


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