GFI1 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 14198-1-AP

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Freight/Packing

Con: 21 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
K-562 cells, HL-60 cells, K-562 cells, mouse thymus tissue, PC-3 cells, Raji cells

Recommended dilution:
WB : 1:500-1:1000

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
growth factor independent 1 transcription repressor

Calculated molecular weight:
45 kDa

Observed molecular weight:
62-66 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
GFI1

Synonyms
FLJ94509, GFI 1, GFI1, Zinc finger protein 163, Zinc finger protein Gfi 1, ZNF163
Background

GFI is a transcriptional repressor that is transiently induced during T-cell differentiation. It has critical roles in enhancing T helper-2 (Th2) cell expansion and in repressing induction of Th17 and CD103-positive inducible regulatory T (Treg) cells [PMID: 19188499]. The growth factor independent 1 (GFI1) transcriptional regulator oncoprotein plays a crucial role in hematopoietic, inner ear, and pulmonary neuroendocrine cell development and governs cell processes as diverse as self-renewal of hematopoietic stem cells, proliferation, apoptosis, differentiation, cell fate specification, and oncogenesis [PMID: 18805794]. The calculated molecular weight of GFI1 protein is about 45 kDa, but the modification of ubiquitinated GIF1 protein is about 62-66 kDa [PMID: 12721361].


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