GGCX Antibody 2 Publications

Rabbit Polyclonal| Catalog number: 16209-1-AP

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Freight/Packing

Con: 33 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
MCF7 cells, HEK-293 cells, HepG2 cells, L02 cells, MCF-7 cells, mouse liver tissue, PC-3 cells

Positive IP detected in:
mouse liver tissue

Positive IHC detected in:
human liver tissue, human brain tissue, human liver tissue

Recommended dilution:
WB : 1:1000-1:4000
IP : 0.5-4.0 ug for IP and 1:1000-1:4000 for WB
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
gamma-glutamyl carboxylase

Calculated molecular weight:
758aa,88 kDa

Observed molecular weight:
88 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
GGCX

Synonyms
FLJ26629, gamma glutamyl carboxylase, GC, GGCX, VKCFD1
Background

GGCX(Gamma-glutamyl carboxylase) is also named as GC and belongs to the vitamin K-dependent gamma-carboxylase family. This 94 kDa (including all modifications, such as the five N-linked glycosylations), is a 5-pass transmembrane protein and a key regulator of blood coagulation(PMID:20518534). It mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide. Defects in GGCX are a cause of combined deficiency of vitamin K-dependent clotting factors type 1 (VKCFD1) and pseudoxanthoma elasticum-like disorder with multiple coagulation factor deficiency (PXEL-MCFD)(PMID:9845520;17110937).


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