KGA/GAM/GAC Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 23549-1-AP

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Con: 74 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
HEK-293 cells, HeLa cells, mouse brain tissue, mouse liver tissue, rat brain tissue

Positive IP detected in:
HEK-293 cells

Positive IHC detected in:
human kidney tissue, human brain tissue

Positive IF detected in:
HEK-293 cells, HeLa cells

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:20-1:200
IF : 1:10-1:100

Product Information


Purification method:
Antigen affinity purification


PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information

Full name:

Calculated molecular weight:
669aa,73 kDa

Observed molecular weight:
58 kDa, 83 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol

AAD20, GAC, GAM, GLS, GLS1, glutaminase, K glutaminase, KGA, KIAA0838, L glutamine amidohydrolase

GLS, also named as GLS1 and KIAA0838, belongs to the glutaminase family. It catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Glutaminase-, glutamate-, and taurine-immunoreactive neurons develop neurofibrillary tangles in Alzheimer's disease.The glutaminase band in AA/C1 cells is more intense than in HT29 cells, in accordance with measurements of glutaminase activity, and had the same molecular mass of approx. 63 kDa(PMID:12408749). Ping Gao et al. (2009) determined that mitochondrial glutaminase expression (GLS, molecular mass of ~58 kDa) is increased ~10-fold in response to Myc. It also reveals a molecular weight of 83-84 kDa as a phosphate-dependent glutaminase(PMID:447624;7512428). GLS has 3 isoforms produced by alternative splicing and this antibody is specific to the 3 isoforms(KGA,GAM,GAC) of GLS.

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