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GPNMB Polyclonal antibody

GPNMB Polyclonal Antibody for ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse and More (1)

Applications

WB, IHC, IF, ELISA

Conjugate

Unconjugated

Cat no : 20338-1-AP

Synonyms

GPNMB, HGFIN, Transmembrane glycoprotein NMB



Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

The immunogen of 20338-1-AP is GPNMB Fusion Protein expressed in E. coli.

Tested Reactivity human, mouse
Cited Reactivityhuman, mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen GPNMB fusion protein Ag14124
Full Name glycoprotein (transmembrane) nmb
Calculated Molecular Weight 64 kDa
Observed Molecular Weight 68 kDa
GenBank Accession NumberBC011595
Gene Symbol GPNMB
Gene ID (NCBI) 10457
RRIDAB_10667459
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

GPNMB also known as HGFIN, osteoactivin, and DC-HIL, is a type I membrane glycoprotein involved in various biological processes, including inflammation, invasion and metastasis of malignant tumors, cell differentiation, and tissue regeneration. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB acts as an osteogenic factor that stimulates osteoblast differentiation in vivo and in vitro.

Publications

SpeciesApplicationTitle

J Cell Physiol

Transcriptome analysis reveals GPNMB as a potential therapeutic target for gastric cancer.

Authors - Feifei Ren
humanIHC

BMC Med Genomics

Genomic profiling of rectal adenoma and carcinoma by array-based comparative genomic hybridization.

Authors - Shi Zhi-Zhou ZZ
mouseWB

Int J Mol Sci

Ocular Albinism Type 1 Regulates Melanogenesis in Mouse Melanocytes.

Authors - Tianzhi Chen
humanWB,IHC

Inflammation

Glycoprotein Nonmetastatic Melanoma Protein B (GPNMB) Ameliorates the Inflammatory Response in Periodontal Disease.

Authors - Rong Song
humanIHC

Pathol Oncol Res

GPNMB-Positive Cells in Head and Neck Squamous Cell Carcinoma-Their Roles in Cancer Stemness, Therapy Resistance, and Metastasis

Authors - Yohei Kawasaki
mouseWB

J Biomater Appl

The anti-inflammatory and osteogenic activity of chitosan/polyvinyl alcohol/graphene oxide/astaxanthin nanofibers membranes in vitro study.

Authors - Xuan Dang