ProGRP Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 14646-1-AP

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Con: 35 μg/150 μl

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Species specificity:
human, chimpanzee

Positive WB detected in:
PC-3 cells, Transfected HEK-293 cells

Positive IHC detected in:
human stomach tissue

Positive IF detected in:
PC-3 cells

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:20-1:200
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
gastrin-releasing peptide

Calculated molecular weight:
16 kDa

Observed molecular weight:
13 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
GRP

Synonyms
BN, gastrin releasing peptide, GRP, GRP 10, preproGRP, proGRP
Background

Gastrin-releasing peptide, also known as GRP, is normally formed by mucosal cells in the gastric antrum and by the D cells of the pancreatic islets, and its main function is to stimulate secretion of HCl by the gastric mucosa. HCl, in turn, inhibits gastrin formation. Its 148-amino acid preproprotein, following cleavage of a signal peptide, is further processed to produce either the 27-amino acid gastrin-releasing peptide or the 10-amino acid neuromedin C. These smaller peptides regulate numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation.These peptides are also likely to play a role in human cancers of the lung, colon, stomach, pancreas, breast, and prostate.


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