TFII I Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 10499-1-AP

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Freight/Packing

Con: 36 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
HEK-293 cells, HEK-293 cells, HeLa cells, Jurkat cells

Positive IHC detected in:
human ovary tumor tissue, human colon cancer tissue, human ovary tumor tissue

Positive IF detected in:
HeLa cells

Positive FC detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:20-1:200
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
general transcription factor II, i

Calculated molecular weight:
112 kDa

Observed molecular weight:
135 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
GTF2I

Synonyms
BAP 135, BAP135, BTK associated protein 135, BTKAP1, DIWS, FLJ38776, FLJ56355, GTF2I, GTFII I, IB291, SPIN, SRF Phox1 interacting protein, TFII I, WBS, WBSCR6
Background

The GTF2I gene encodes a transcription factor. It negatively regulates agonist-induced calcium entry into cells by interfering with expression of the cation channel TRPC3 at the plasma membrane [PMID: 17023658]. As a transcription factor and/or as a regulator of intracellular calcium levels, GTF2I may play a role in the molecular basis of anxiety[PMID: 22578324]. It interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation [PMID: 16738337].


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