H6PD Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 15255-1-AP

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Freight/Packing

Con: 53 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
HepG2 cells, HeLa cells, mouse liver tissue

Positive IP detected in:
HepG2 cells

Positive IHC detected in:
human hepatocirrhosis tissue, human hepatocirrhosis tissue, human liver cancer tissue

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)

Calculated molecular weight:
89 kDa

Observed molecular weight:
89-95 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
H6PD

Synonyms
6PGL, DKFZp686A01246, G6PDH, GDH, H6PD
Background

Hexose-6-phosphate dehydrogenase (H6PD) is also named as GDH,6PGL. It is the main NADPH generating enzyme in the lumen of the endoplasmic reticulum. H6PD is regarded as an ancillary enzyme in prereceptorial glucocorticoid activation and probably acts as a nutrient sensor and as a prosurvival factor(PMID:21620971). H6PD has been shown to be a glycoprotein and tissue differences in glycosylation status might explain both the difference in migration on SDS-PAGE gels as well as in activity. Defects in H6PD are a cause of cortisone reductase deficiency (CRD). This antibody is specific to H6PD.


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