HMG20A Antibody 2 Publications

Rabbit Polyclonal| Catalog number: 12085-2-AP

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Freight/Packing

Con: 38 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
Jurkat cells

Positive IP detected in:
Jurkat cells

Positive IHC detected in:
human pancreas cancer tissue

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:20-1:200
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
high-mobility group 20A

Calculated molecular weight:
347aa,40 kDa

Observed molecular weight:
45-50 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
HMG20A

Synonyms
FLJ10739, high mobility group 20A, HMG box containing protein 20A, HMG20A, HMGX1, HMGXB1
Background

The HMG (high mobility group) proteins are nonhistone chromosomal proteins that is present in almost all eukaryotic cells, and it functions to stabilize nucleosome formation and acts as a transcription-factor-like protein that regulates the expression of several genes. HMG20A has a role in the initiation of neuronal differentiation by activating REST-responsive genes, and it also nvolves in the recruitment of the histone methyltransferase MLL and consequent increased methylation of histone H3 lysine 4. HMG20A (for inhibitor of BRAF35) overcomes the repressive effects of the neuronal silencer REST and activates REST-responsive genes through the modulation of histone methylation


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