HMGCR Antibody 4 Publications

Rabbit Polyclonal| Catalog number: 13533-1-AP

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Con: 35 μg/150 μl

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Species specificity:
human, mouse, rat

Positive IHC detected in:
human liver cancer tissue, human heart tissue, human liver cancer tissue

Recommended dilution:
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
3-hydroxy-3-methylglutaryl-Coenzyme A reductase

Calculated molecular weight:
888aa,95 kDa

Observed molecular weight:

GenBank accession number:

Gene ID (NCBI):

Gene symbol
HMGCR

Synonyms
HMG CoA reductase, HMGCR
Background

HMGCR(3-hydroxy-3-methylglutaryl-coenzyme A reductase) is also named as HMG-CoA reductase and belongs to the HMG-CoA reductase family. This protein exists as a 97-kDa glycoprotein in the endoplasmic reticulum (ER) and is the rate-determining enzyme of the biosynthesis pathway(PMID:15830340).The ectopic expression of either full-length HMGCR or its novel splice variant promotes dysregulation of the MVA pathway. And the ectopic expression of cHMGCR-FL(60 kDa) and cHMGCR-D13(55 kDa) can be detected in HepG2 cells(PMID:20696928).This protein is also can exsit as a oligomer(PMID:20696928).


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