HOOK1 Antibody 2 Publications

Rabbit Polyclonal| Catalog number: 10871-1-AP

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Freight/Packing

Con: 40 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
HEK-293 cells, human brain tissue

Positive IP detected in:
mouse brain tissue

Positive IHC detected in:
human colon cancer tissue

Positive IF detected in:
HEK-293 cells

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:20-1:200
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
hook homolog 1 (Drosophila)

Calculated molecular weight:
85 kDa

Observed molecular weight:
85 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
HOOK1

Synonyms
h hook1, hHK1, HK1, hook homolog 1 (Drosophila), HOOK1, Protein Hook homolog 1
Background

HOOK1, an orthologue of the Drosophila Hook protein, is a member of the microtubule-binding HOOK family of cytosolic coiled-coil proteins (HOOK1, HOOK2, HOOK3). These proteins contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. HOOK1 is required for spermatid differentiation. It is probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton. HOOK1 is a component of the FTS/Hook/FHIP complex which functions to promote vesicle trafficking and/or fusion via the HOPS (homotypic vesicular protein sorting) complex.


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