HTRA2 Antibody 3 Publications

Rabbit Polyclonal| Catalog number: 15775-1-AP

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Freight/Packing

Con: 28 μg/150 μl

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Species specificity:
human, mouse, rat, monkey

Positive WB detected in:
HEK-293 cells, COS-7 cells, HEK-293 cells, HeLa cells, human heart tissue, Jurkat cells, MCF-7 cells, mouse skeletal muscle tissue, Raji cells

Positive IP detected in:
Raji cells

Positive IHC detected in:
human kidney tissue, human colon tissue, human kidney tissue, human thyroid tissue

Recommended dilution:
WB : 1:1000-1:4000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
HtrA serine peptidase 2

Calculated molecular weight:
49 kDa

Observed molecular weight:
36 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
HTRA2

Synonyms
HtrA serine peptidase 2, HTRA2, OMI, PARK13, PRSS25, Serine protease 25, Serine proteinase OMI
Background

HTRA2(High temperature requirement protein A2) is also named as OMI, PRSS25 and belongs to the peptidase S1B family. HTRA2 normally exists in the mitochondria, can cause MMP3 activation in the cytosol under a cell stress condition, which can ultimately lead to demise of dopaminergic neuronal cells(PMID: 22265821). It inhibits mitochondrial superoxide generation, stabilizes mitochondrial membrane potential, and prevents apoptosis at baseline and in response to extracellular inducers of mitochondrial stress(PMID: 18772386). This protein has 4 isoforms produced by alternative splicing.


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