iduronate 2 sulfatase Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 17140-1-AP

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Con: 26 μg/150 μl

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Tested Applications

Applications:
ELISA
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Species specificity:
human, mouse, rat

Recommended dilution:

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
iduronate 2-sulfatase

Calculated molecular weight:
312aa,35 kDa;550aa,62 kDa

Observed molecular weight:

GenBank accession number:

Gene ID (NCBI):

Gene symbol
IDS

Synonyms
IDS, iduronate 2 sulfatase, Idursulfase
Background

Iduronate 2-sulfatase (IDS) is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations causing IDS deficiency in humans result in the lysosomal storage of these glycosaminoglycans and Hunter syndrome, an X chromosome-linked disease. IDS is synthesized as two precursor forms of 76 and 90 kDa that are converted, through a 62 kDa intermediate, to 55 and 45 kDa mature polypeptides due to an internal proteolytic cleavage (PMID: 10838181).


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