IGFBP1 Antibody 3 Publications

Rabbit Polyclonal| Catalog number: 13981-1-AP

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Con: 33 μg/150 μl

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Species specificity:
human

Positive WB detected in:
human placenta tissue

Positive IHC detected in:
human placenta tissue, human stomach tissue

Recommended dilution:
WB : 1:200-1:1000
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
insulin-like growth factor binding protein 1

Calculated molecular weight:
28 kDa

Observed molecular weight:
35 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
IGFBP1

Synonyms
AFBP, hIGFBP 1, IBP 1, IBP1, IGF binding protein 1, IGF BP25, IGFBP 1, IGFBP1, Placental protein 12, PP12
Background

Insulin-like growth factor (IGF)-binding proteins (IGFBPs) family contains members like IGFBP-1, -2, -3, -4,-5 and-6. IGFBPs prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. IGF-I physically interacts with IGFBP-1 and that IGFBP-1 also binds to an integrin receptor, but the effect of IGFBP-1 on cell migration may be independent of IGF-I and is probably mediated through the alpha 5 beta 1 integrin. Transgenic mice models demonstrated that IGFBPs played important roles in the pathogenesis of obesity and insulin resistance. Studies conducted in humans demonstrated the close relation between IGFBPs and the components of the metabolic syndrome.


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