IL 1 alpha Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 16765-1-AP

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Freight/Packing

Con: 25 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
mouse liver tissue, human placenta tissue, Jurkat cells, mouse lung tissue

Positive IF detected in:
RAW 264.7 cells

Recommended dilution:
WB : 1:500-1:1000
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
interleukin 1, alpha

Calculated molecular weight:
271aa,31 kDa

Observed molecular weight:
31 kDa,17 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
IL1A

Synonyms
Hematopoietin 1, IL 1 alpha, IL 1A, IL1, IL1 ALPHA, IL1A, IL1F1, Interleukin 1 alpha, interleukin 1, alpha
Background

Interleukin-1α (IL-1α) is a protein that plays a crucial role in the regulation of a number of key cellular processes. IL-1α is a cytokine and a potent mediator of body’s response to inflammation, microbial invasion, tissue injury and immunological response. In addition, recent studies suggest that IL-1α also has a role in wound healing, rheumatoid arthritis, Alzheimer’s disease and tumor growth. IL-1α functions as an alarmin during the process of sterile inflammation. It serves as a signal from dying cells to potentiate the inflammatory response, increasing the expression of other secreted factors like IL-6 and IL-8. IL-1α was found to affect the cell cycle of osteosarcoma cell to reduce cell growth.


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