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IL 1 alpha Antibody 2 Publications

Rabbit Polyclonal| Catalog number: 16765-1-AP

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Con: 25 μg/150 μl

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Tested Applications

Applications:
WB, IF, ELISA
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Images See all

IL 1 alpha Antibody WB mouse liver tissue 16765-1-AP

mouse liver tissue were subjected to SDS PAGE followed by western blot with 16765-1-AP( IL 1 alpha antibody at dilution of 1:600 incubated at room temperature for 1.5 hours

IL 1 alpha Antibody IF RAW 264.7 cells 16765-1-AP

Immunofluorescent analysis of ( -20℃ Ethanol ) fixed RAW 264.7 cells using 16765-1-AP(IL 1 alpha antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Species specificity:
human, mouse
Positive WB detected in:
mouse liver tissue, mouse lung tissue, Jurkat cells, human placenta tissue
Positive IF detected in:
RAW 264.7 cells
Recommended dilution:
WB : 1:500-1:1000
IF : 1:50-1:500
Sample-dependent, check data in Validation tab

Product Information

Source:
Rabbit
Purification method:
Antigen affinity purification
Isotype:
IgG
Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information

Immunogen:
IL 1 alpha fusion protein Ag10339
Full name:
interleukin 1, alpha
Calculated molecular weight:
271aa,31 kDa
Observed molecular weight:
30 kDa,17 kDa
GenBank accession number:
BC013142
Gene ID (NCBI):
3552
Gene symbol
IL1A
Synonyms
Hematopoietin 1, IL 1 alpha, IL 1A, IL1, IL1 ALPHA, IL-1 alpha, IL1A, IL1F1, Interleukin 1 alpha, interleukin 1, alpha

Background

Interleukin-1α (IL-1α) is a protein that plays a crucial role in the regulation of a number of key cellular processes. IL-1α is a cytokine and a potent mediator of body’s response to inflammation, microbial invasion, tissue injury and immunological response. In addition, recent studies suggest that IL-1α also has a role in wound healing, rheumatoid arthritis, Alzheimer’s disease and tumor growth. IL-1α functions as an alarmin during the process of sterile inflammation. It serves as a signal from dying cells to potentiate the inflammatory response, increasing the expression of other secreted factors like IL-6 and IL-8. IL-1α was found to affect the cell cycle of osteosarcoma cell to reduce cell growth. IL1-alpha is initially translated as approximately 30-kD polypeptides that are processed to approximately 17.5-kD polypeptides prior to, or during, release from macrophages.


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