IRF7 Antibody 2 Publications

Rabbit Polyclonal| Catalog number: 22392-1-AP

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Freight/Packing

Con: 52 μg/150 μl

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Species specificity:
human

Positive WB detected in:
HEK-293 cells

Positive IP detected in:
HEK-293 cells

Positive IHC detected in:
human tonsillitis tissue

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen Affinity purified

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
interferon regulatory factor 7

Calculated molecular weight:
516aa,56 kDa

Observed molecular weight:
80 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
IRF7

Synonyms
interferon regulatory factor 7, IRF 7, IRF 7H, IRF7, IRF7A
Background

IRF-7 (interferon regulatory factor 7) is a member of the interferon regulatory transcription factor (IRF) family. IRF-7 has been shown to play a role in the transcriptional activation of virus-inducible cellular proteins, including interferon beta chain proteins. Inducible expression of IRF-7 is largely restricted to lymphoid tissue. Four transcript variants encoding distinct isoforms (A,B,C and D) have been identified for this (PMID:9786932).The active IRF7A exists as a dimer form ~80 kDa(PMID:11073981). The MW 67-70 kDa has been reported in some papers (PMID:9786932; 22951831).Various posttranslational modifications of IRF7 including phosphorylation, ubiquitination, sumoylation and acetylation are identified (PMID:22951831).This antibody is a rabbit polyclonal antibody raised against the C-terminal 349 amino acid residues of human IRF7 D.


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