Integrin alpha-1 Antibody 2 Publications

Rabbit Polyclonal| Catalog number: 22146-1-AP

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Con: 31 μg/150 μl

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Species specificity:
human, rat

Positive WB detected in:
HepG2 cells, SMMC-7721 cells, HeLa cells

Positive IHC detected in:
human tonsillitis tissue

Positive FC detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
integrin, alpha 1

Calculated molecular weight:
1179aa,131 kDa

Observed molecular weight:
180 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
ITGA1

Synonyms
CD49a, Integrin alpha 1, integrin, alpha 1, ITGA1, Laminin and collagen receptor, VLA 1, VLA1
Background

The integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix ligands, cell-surface ligands, and soluble ligands (PMID: 17543136). They are transmembrane αβ heterodimers and at least 24 distinct integrin heterodimers are formed by the combination of 18 α and eight β known subunits (PMID: 17543136; 20029421). In addition to mediating cell adhesion, integrins also play important roles in modulating signal transduction pathways that control cellular responses including migration, proliferation, differentiation, and apoptosis (PMID:19118207). Integrin alpha-1 (ITGA1, CD49a) combines with the beta 1 subunit (ITGB1, CD29) to form a cell-surface receptor for collagen and laminin. This receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis.


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