JAK1 Antibody 0 Publications

Mouse Monoclonal| Catalog number: 66466-1-Ig |CloneNo.: 3H7A8

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Freight/Packing

Con: 150 μg/150 μl

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Species specificity:
human, rat

Positive WB detected in:
Jurkat cells, rat spleen tissue

Positive IHC detected in:
human breast cancer tissue, human cervical cancer tissue

Recommended dilution:
WB : 1:1000-1:6000
IHC : 1:100-1:400

Product Information


Source:
Mouse

Purification method:
Protein A purification

Isotype:
IgG2b

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
Janus kinase 1 (a protein tyrosine kinase)

Calculated molecular weight:
1154aa,133 kDa

Observed molecular weight:
133 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
JAK1

Synonyms
JAK 1, JAK1, JAK1A, JAK1B, Janus kinase 1, JTK3, Tyrosine protein kinase JAK1
Background

Janus kinase 1(JAK1), is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. JAK1 is essential for signaling for certain type I and type II cytokines. JAK1 plays a critical role in initiating responses to multiple major cytokine receptor families. Expression of JAK1 in cancer cells enables individual cells to contract, potentially allowing them to escape their tumor and metastasize to other parts of the body.


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