KEAP1 Antibody 81 Publications

Rabbit Polyclonal| Catalog number: 10503-2-AP

Featured Product KD/KO validated

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Con: 56 μg/150 μl

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Species specificity:
human, mouse, rat, monkey

Positive WB detected in:
Jurkat cells, HEK-293 cells, HepG2 cells

Positive IP detected in:
mouse skeletal muscle tissue

Positive IHC detected in:
human lung cancer tissue, human breast cancer tissue, human skeletal muscle tissue

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
kelch-like ECH-associated protein 1

Calculated molecular weight:
624aa,70 kDa

Observed molecular weight:
70 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
KEAP1

Synonyms
Cytosolic inhibitor of Nrf2, INrf2, KEAP1, Kelch like protein 19, KIAA0132, KLHL19
Background

KEAP1, also named as INRF2, KIAA0132 and KLHL19, is part of a multiprotein complex that contains the CUL3-ROC1 ubiquitin ligase, which can ubiquitinate the N-terminal domain of NRF2[PMID: 20173742]. Two molecules of KEAP1 bind to two distinct sites in the N-terminal region of NRF2, the ETGE and DLG sites, which affect the KEAP1-NRF2 interaction and/or its physiological consequences[PMID: 22215675]. KEAP1 retains NFE2L2/NRF2 in the cytosol. It functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1[PMID: 20427290]. It also retains BPTF in the cytosol. This antibody is a rabbit polyclonal antibody raised against residues near the C terminus of human KEAP1.

Read more about this antibody on the blog:http://blog.ptglab.com/index.php/nsclc-research-anti-keap1-antibody-helps-uncover-targets-biomarker-potential/


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