DYNC1H1  Antibody 10 Publications

Rabbit Polyclonal| Catalog number: 12345-1-AP

Featured Product KD/KO validated

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Con: 30 μg/150 μl

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Species specificity:
human, rat, zebrafish, mouse

Positive WB detected in:
HeLa cells, HeLa cells, human brain tissue, mouse brain tissue

Positive IHC detected in:
human breast cancer tissue, human breast cancer tissue, human testis tissue

Positive IF detected in:
MCF-7 cells

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:20-1:200
IF : 1:20-1:200

Product Information


Purification method:
Antigen affinity purification


PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information

Full name:
dynein, cytoplasmic 1, heavy chain 1

Calculated molecular weight:
4646aa,532 kDa

Observed molecular weight:
532 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol

DHC1, DHC1a, DKFZp686P2245, DNCH1, Dnchc1, DNCL, DNECL, DYHC, DYNC1H1, Dynein heavy chain, cytosolic, HL 3, KIAA0325, p22

Dyneins are a group of microtubule-activated ATPases that serve to convert chemical energy into mechanical energy. It can be divided into 2 large subgroups, namely, the axonemal and cytoplasmic dyneins. The conventional cytoplasmic dynein are comprised of 2 heavy chain polypeptides and a number of intermediate and light chains. DYNC1H1 is a cytoplasmic dynein and belongs to the dynein heavy chain family. It acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. DYNC1H1 has been implicated in the degeneration of dopaminergic neuron axons and motor neurons in PD patients..

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