DYNC1H1  Antibody 9 Publications

Rabbit Polyclonal| Catalog number: 12345-1-AP

Featured Product KD/KO validated

  • Print page
  • Download PDF

-_-

Freight/Packing

Con: 30 μg/150 μl

Choose size:

Please visit your regions distributor:


Species specificity:
human, rat, zebrafish, mouse

Positive WB detected in:
HeLa cells, HeLa cells, human brain tissue, mouse brain tissue

Positive IHC detected in:
human breast cancer tissue, human breast cancer tissue, human testis tissue

Positive IF detected in:
MCF-7 cells

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:20-1:200
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
dynein, cytoplasmic 1, heavy chain 1

Calculated molecular weight:
4646aa,532 kDa

Observed molecular weight:
532 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
DYNC1H1

Synonyms
DHC1, DHC1a, DKFZp686P2245, DNCH1, Dnchc1, DNCL, DNECL, DYHC, DYNC1H1, Dynein heavy chain, cytosolic, HL 3, KIAA0325, p22
Background

Dyneins are a group of microtubule-activated ATPases that serve to convert chemical energy into mechanical energy. It can be divided into 2 large subgroups, namely, the axonemal and cytoplasmic dyneins. The conventional cytoplasmic dynein are comprised of 2 heavy chain polypeptides and a number of intermediate and light chains. DYNC1H1 is a cytoplasmic dynein and belongs to the dynein heavy chain family. It acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. DYNC1H1 has been implicated in the degeneration of dopaminergic neuron axons and motor neurons in PD patients..


Back
to top