LARG Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 22441-1-AP

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Con: 74 μg/150 μl

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Species specificity:

Positive WB detected in:
Jurkat cells, HeLa cells

Positive IHC detected in:
human testis tissue

Positive IF detected in:
HepG2 cells, HeLa cells

Recommended dilution:
WB : 1:1000-1:4000
IHC : 1:20-1:200
IF : 1:20-1:200

Product Information


Purification method:
Antigen affinity purification


PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information

Full name:
Rho guanine nucleotide exchange factor (GEF) 12

Calculated molecular weight:
1544aa,173 kDa

Observed molecular weight:
220 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol

ARHGEF12, DKFZp686O2372, KIAA0382, LARG, Leukemia associated RhoGEF, PRO2792

LARG, also known as ARHGEF12, is one of three regulator of G protein signalling (RGS) domain-containing RhoGEFs. LARG activates the ROCK pathway downstream of Gα12/13 signaling, leading to cytoskeletal reorganisation.LARG performs this activity either as a homodimer or as a heterodimer with Arhgef11. LARG has been implicated in many diseases, including cancer, heart disease, and in HIV viral replication. LARG is phosphorylated and dephosphorylated during mitosis and that Cdk1 is the mitotic kinase responsible for LARG phosphorylation. We got 220 kDa in western blotting, maybe due to its phosphorylation.

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