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LBR Antibody 2 Publications

Rabbit Polyclonal| Catalog number: 12398-1-AP

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Con: 32 μg/150 μl

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Tested Applications
Applications:
ELISA, FC, IF, IP, WB
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Images See all

12398-1-AP;A375 cells

A375 cells were subjected to SDS PAGE followed by western blot with 12398-1-AP(LBR antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours

12398-1-AP;Hela cells

Immunofluorescent analysis of Hela cells, using LBR antibody 12398-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).

12398-1-AP;A375 cells

IP Result of anti-LBR (IP:12398-1-AP, 3ug; Detection:12398-1-AP 1:500) with A375 cells lysate 3200ug.

12398-1-AP;Jurkat cells

1X10^6 Jurkat cells were stained with 0.2ug LBR antibody (12398-1-AP, red) and control antibody (blue). Fixed with 4% PFA blocked with 3% BSA (30 min). Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L) with dilution 1:1500.

Species specificity:
human, mouse, rat
Positive WB detected in:
A375 cells, human brain tissue
Positive IP detected in:
A375 cells
Positive IF detected in:
Hela cells, HeLa cells, HepG2 cells
Positive FC detected in:
Jurkat cells
Recommended dilution:
WB : 1:1000-1:4000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IF : 1:10-1:100

Product Information

Source:
Rabbit
Purification method:
Antigen affinity purification
Isotype:
IgG
Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information

Immunogen:
LBR fusion protein ag3088
Full name:
lamin B receptor
Calculated molecular weight:
615aa,71 kDa
Observed molecular weight:
58 kDa
GenBank accession number:
BC020079
Gene ID (NCBI):
3930
Gene symbol
LBR
Synonyms
DHCR14B, FLJ43126, lamin B receptor, LBR, LMN2R, PHA
Background

Lamin-B receptor (LBR) belongs to the ERG4/ERG24 family. LBR is a 58-kDa integral protein of the nuclear envelope inner membrane and anchors the lamina and the heterochromatin to the inner nuclear membrane. LBR may mediate interaction between chromatin and lamin B. Mutations of the LBR gene has been associated with autosomal recessive HEM/Greenberg skeletal dysplasia.


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