LDLR Antibody 17 Publications

Rabbit Polyclonal| Catalog number: 10785-1-AP

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Freight/Packing

Con: 46 μg/150 μl

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Species specificity:
human, mouse, Chicken, Hamster, Landrace, pig, rat

Positive WB detected in:
mouse brain tissue, HeLa cells, HL-60 cells, human brain tissue, Jurkat cells, NIH/3T3 cells, Raji cells

Positive IP detected in:
HeLa cells

Positive IHC detected in:
human brain tissue, human brain tissue, human colon cancer tissue, human pancreas tissue

Positive IF detected in:
HeLa cells

Positive FC detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:50-1:500
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
low density lipoprotein receptor

Calculated molecular weight:
95 kDa

Observed molecular weight:
150-160 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
LDLR

Synonyms
FH, FHC, LDL receptor, LDLR
Background

LDLR (low density lipoprotein receptor) is a member of the LDL receptor gene family and is involved in receptor-mediated endocytosis of specific ligands. The LDLR is a cell surface glycoprotein that scavenges LDL from the blood and regulates plasma LDL cholesterol. The cytoplasmic domain of the LDL receptor is necessary for the receptor to cluster in coated pits, which promotes the rapid endocytosis of bound LDL. The protein is highly glycosylated through N- and O-linkages and thus migrates at 100 to 160 kDa bands on SDS-PAGE.


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