LGALS3BP Antibody 9 Publications

Rabbit Polyclonal| Catalog number: 10281-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 53 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
COLO 320 cells, A549 cells

Positive IP detected in:
HepG2 cells, HEK-293 cells

Positive IHC detected in:
human oesophagus cancer tissue

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB
IHC : 1:50-1:500
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
lectin, galactoside-binding, soluble, 3 binding protein

Calculated molecular weight:
585aa,65 kDa

Observed molecular weight:
65-90 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
LGALS3BP

Synonyms
90K, BTBD17B, Galectin 3 binding protein, LGALS3BP, M2BP, Mac 2 binding protein, MAC 2 BP, MAC2BP, Tumor associated antigen 90K
Background

The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS3BP is a widely expressed, secreted galectin. It has been found elevated in the serum of patients with various types of breast, lung, colorectal, ovary, and endometrial cancer, and in those infected by the human immunodeficiency virus (HIV). High expression levels of LGALS3BP are associated with a shorter survival, the occurrence of metastasis or a reduced response to chemotherapy. The native protein binds specifically to a human macrophage-associated lectin known as Mac-2 and also binds galectin 1. It appears to be implicated in immune response associated with natural killer (NK) and lymphokine-activated killer (LAK) cell cytotoxicity. Immunoblotting showed that LGALS3BP is likely contained in breast milk, serum, semen, saliva, urine, and tears.


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