LONP1 Antibody 0 Publications

Mouse Monoclonal| Catalog number: 66043-1-Ig |CloneNo.: 1C6C12

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Freight/Packing

Con: 234 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
Jurkat cells, human liver tissue, ROS1728 cells, HSCT6 cells, human heart tissue, RAW 264.7 cells, L02 cells, HEK-293 cells

Positive IHC detected in:
human lung cancer tissue, human heart tissue, human liver tissue, human lung cancer tissue

Positive IF detected in:
C6 cells

Recommended dilution:
WB : 1:1000-1:10000
IHC : 1:400-1:1600
IF : 1:10-1:100

Product Information


Source:
Mouse

Purification method:
Protein G purification

Isotype:
IgG1

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
lon peptidase 1, mitochondrial

Calculated molecular weight:
106 kDa

Observed molecular weight:
100 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
LONP1

Synonyms
hLON, LON, lon peptidase 1, mitochondrial, Lon protease like protein, LonHS, LONP, LONP1, PIM1, PRSS15, Serine protease 15
Background

LONP1(Lon protease homolog, mitochondrial) is also named as LONP, LONHS, HLON, LON, PRSS15, PIM1, MGC1498 and belongs to the peptidase S16 family. It seems to play a major role in the elimination of oxidatively modified proteins in the mitochondrial matrix(PMID:18021745). LONP1, also a nuclearly encoded and mitochondrially located stress-responsive protease, is involved in heme-mediated ALAS-1 turnover(PMID:21659532). It recognizes specific surface determinants or folds, initiates proteolysis at solvent-accessible sites, and generates unfolded polypeptides that are then processively degraded(PMID:15870080).


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