MAF Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 55013-1-AP

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Freight/Packing

Con: 53 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
A431 cells, multi-cells/tissue

Positive IP detected in:
A431 cells

Positive IHC detected in:
human kidney tissue

Positive IF detected in:
A431 cells

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:20-1:200
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Immunogen:
Peptide

Full name:
v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)

Calculated molecular weight:
42 kDa

Observed molecular weight:
48-50 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
MAF

Synonyms
c MAF, cMAF, MAF, Proto oncogene c Maf, Transcription factor Maf
Background

MAF, also named as c-Maf, belongs to the bZIP family and Maf subfamily. MAF acts as a transcriptional activator or repressor. It is involved in embryonic lens fiber cell development. MAF increases T cell susceptibility to apoptosis by interacting with MYB and decreasing BCL2 expression. Together with PAX6, it transactivates strongly the glucagon gene promoter through the G1 element. MAF activates transcription of the CD13 proximal promoter in endothelial cells. It is involved in the initial chondrocyte terminal differentiation and the disappearance of hypertrophic chondrocytes during endochondral bone development. When overexpressed, MAF represses anti-oxidant reponse element (ARE)-mediated transcription. It is involved either as an oncogene or as a tumor suppressor, depending on the cell context. A chromosomal aberration involving MAF is found in some forms of multiple myeloma (MM). Defects in MAF are the cause of cataract pulverulent juvenile-onset MAF-related (CAPJOM). Defects in MAF are the cause of cataract congenital cerulean type 4 (CCA4). The antibody is specific to MAF.


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