MARCH8 Antibody 3 Publications

Rabbit Polyclonal| Catalog number: 14119-1-AP

Featured Product KD/KO validated

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Con: 20 μg/150 μl

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Species specificity:
human, mouse, zebrafish

Positive WB detected in:
mouse testis tissue

Positive IP detected in:
mouse lung tissue

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
membrane-associated ring finger (C3HC4) 8

Calculated molecular weight:
33 kDa

Observed molecular weight:
30-33 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
MARCH8

Synonyms
c MIR, MARCH VIII, MARCH8, MIR, RING finger protein 178, RNF178
Background

MARCH8(Membrane-associated RING finger protein 8) is also named as MIR, RNF178 and belongs to the RING zinc finger protein family. It functions as an E3 ubiquitin ligase for immune recognition-related molecules (e.g. major histocompatibility complex class I, B7-2, and ICAM-1). It plays a key role in controlling MHC class II surface expression by regulated ubiquitination of a lysine residue in the beta-chain(PMID:22761441).


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