MCL1 Antibody 26 Publications

Rabbit Polyclonal| Catalog number: 16225-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 51 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
Raji cells, A431 cells, HeLa cells, HL-60 cells, human brain tissue, human liver tissue, Jurkat cells, K-562 cells, mouse spleen tissue

Positive IP detected in:
Raji cells

Positive IHC detected in:
human tonsillitis tissue, human cervical cancer tissue, human lung cancer tissue, human pancreas tissue, human tonsillitis tissue

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
myeloid cell leukemia sequence 1 (BCL2-related)

Calculated molecular weight:
350aa,37 kDa

Observed molecular weight:
40 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
MCL1

Synonyms
EAT, Mcl 1, Mcl 1l, Mcl 1s Delta TM, MCL1, mcl1/EAT, MCL1L, MCL1S, TM
Background

MCL-1 is an anti-apoptotic member of the Bcl-2 family originally isolated from the ML-1 human myeloid leukemia cell line. Similar to BCL2 and BCL2L1, MCL1 can interact with BAX and/or BAK1 to inhibit mitochondria-mediated apoptosis. Mcl-1 is critical for the proliferation and survival of myeloma cells in vitro, and overexpression of Mcl-1 protein in myeloma cells is associated with relapse and short event-free survival in multiple myeloma patients. Recent studies show that MCL-1 is upregulated in numerous haematological and solid tumour malignancies. Therefore, MCL-1 has been suggested as a potential new therapeutic target. MCL-1 can be alternatively spliced into a long form (MCL-1L, 40 kDa) or a short form (MCL-1S, 30 kDa). (PMID: 15467463, PMID: 15147382)


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