MEKK3 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 21072-1-AP

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Freight/Packing

Con: 106 μg/150 μl

Choose size:

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Species specificity:
human

Positive WB detected in:
mouse liver tissue

Positive IP detected in:
mouse liver tissue

Positive IHC detected in:
human liver cancer tissue

Recommended dilution:
WB : 1:200-1:1000
IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB
IHC : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
mitogen-activated protein kinase kinase kinase 3

Calculated molecular weight:
657aa,74 kDa

Observed molecular weight:
71kDa, 74kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
MAP3K3

Synonyms
MAP3K3, MAPK/ERK kinase kinase 3, MAPKKK3, MEK kinase 3, MEKK 3, MEKK3
Background

The mitogen-activated protein/ERK kinase kinase 3 (MEKK3) is a member of a family of MEKK/Ste11 serine/threonine protein kinases. One function of MEKK3 is to serve as an upstream regulatory kinase in the mitogen-activated protein kinase cascade, however, it also plays a critical role in other signaling pathways. MEKK3 regulates several important functions including cell survival and proliferation. It is ubiquitously expressed in multiple tissues and has been found in complexes with scaffold proteins and other kinases. (PMID: 18206350).Cerebral cavernous malformations (CCMs) complex regulation of MEKK3 is essential during vertebrate heart development. MEKK3 signalling and KLF2/4 may be targeted to develop new CCM therapeutics.


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