MGEA5 Antibody 0 Publications

Mouse Monoclonal| Catalog number: 66033-1-Ig |CloneNo.: 3B9H7

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Con: 126 μg/150 μl

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Species specificity:
human

Positive WB detected in:
Human brain tissue, MCF7 cells

Positive IHC detected in:
human meningioma tissue, human gliomas tissue

Positive IF detected in:
HepG2 cells, Hela cells

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:20-1:200
IF : 1:20-1:200

Product Information


Source:
Mouse

Purification method:
Protein G purification

Isotype:
IgG1

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
meningioma expressed antigen 5 (hyaluronidase)

Calculated molecular weight:
103 kDa

Observed molecular weight:
75kD,130kD

GenBank accession number:

Gene ID (NCBI):

Gene symbol
MGEA5

Synonyms
Beta N acetylhexosaminidase, Bifunctional protein NCOAT, FLJ11229, FLJ23355, HAT, HEXC, Hexosaminidase C, KIAA0679, MEA5, Meningioma expressed antigen 5, MGEA5, N acetyl beta glucosaminidase, NCOAT, O GlcNAcase, OGA
Background

Human meningioma-expressed antigen 5 (MGEA5) has two putative domains including protein O-GlcNAcase domain and histone acetyltransferase domain, therefore it is often called bifunctional protein NCOAT. Three isoforms of MEGE5 are produced by alternative splicing. MGEA5 was found to be regulated to reduce the state of glycosylation of transcitpional activators while increasing the acetylation of histones to allow for the concerted activation of eukaryotic gene transcription, for instance, acetylation of Lys8 of histone H4 and Lys 14 of histone H3 are resulted from acetyltransferase activity. In addition, single nucleotide polymorphism in MGE5A is associated with type 2 diabetes in Mexican Americans. Two bands at 130kDa and 75 kDa could be detected using the present mouse monopolyclonal antibody 66033-1-Ig, which is consistent with results in a related reference (PubMed:11341771).


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