MGP Antibody 0 Publications

Mouse Monoclonal| Catalog number: 60055-1-Ig |CloneNo.: 1A1C3

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Freight/Packing

Con: 150 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
Transfected HEK-293 cells, human brain tissue, human kidney tissue

Positive IHC detected in:
human gliomas tissue,human brain tissue, human lung tissue, human heart tissue, human kidney tissue

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:400-1:1600

Product Information


Source:
Mouse

Purification method:
Caprylic acid/ammonium sulfate precipitation

Isotype:
IgG2a

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
matrix Gla protein

Calculated molecular weight:
103aa,13 kDa

Observed molecular weight:
12 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
MGP

Synonyms
GIG36, matrix Gla protein, MGLAP, MGP, NTI
Background

Matrix Gla protein (MGP) is is a vitamin K-dependent, extracellular matrix protein. MGP plays a pivotal role in preventing soft tissue calcification and local mineralization of the vascular wall. Vitamin K deficiency leads to inactive uncarboxylated MGP (ucMGP), which accumulates at sites of arterial calcification. However MGP is synthesized in many tissues and is especially enriched in embryonic tissues and in cancer cells. Defects in MGP are the cause of Keutel syndrome (KS), which is an autosomal recessive disorder characterized by abnormal cartilage calcification, peripheral pulmonary stenosis neural hearing loss and midfacial hypoplasia.


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