MOG Antibody 3 Publications

Rabbit Polyclonal| Catalog number: 12690-1-AP

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Con: 41 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
mouse brain tissue

Recommended dilution:
WB : 1:500-1:1000

Product Information


Purification method:
Antigen affinity purification


PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information

Full name:
myelin oligodendrocyte glycoprotein

Calculated molecular weight:
295aa,34 kDa

Observed molecular weight:
28 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol

MOG, MOGIG 2, myelin oligodendrocyte glycoprotein

Myelin/oligodendrocyte glycoprotein (MOG), a 26-to 28-kDa glycoprotein, a myelin antigen at the outer surface of the central nervous system (CNS) myelin sheath, which may trigger T-cell as well as B-cell responses. It therefore constitutes a pivotal target for autoimmune responses, which result in inflammation and also demyelination in the CNS. Its presence on the outer- most lamellae of mature CNS myelin and its late appearance during myelinogenesis suggest that it contributes to myelin maturation or maintenance. 10 isoforms of MOG produced by alternative splicing have been described, and heterodimers may be formed between the different isoforms. Defects in MOG are the cause of narcolepsy type 7 (NRCLP7), a neurological disabling sleep disorder characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, cataplexy, hypnagogic hallucinations, and sleep paralysis. Role of MOG in the pathogenesis of multiple sclerosis (MS) has been reported but remains to be clarified.

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