MTHFD1L Antibody 3 Publications

Rabbit Polyclonal| Catalog number: 16113-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 38 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
HepG2 cells, COLO 320 cells, HeLa cells, mouse ovary tissue

Positive IP detected in:
HeLa cells

Positive IHC detected in:
human colon cancer tissue

Recommended dilution:
WB : 1:500-1:3000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like

Calculated molecular weight:
978aa,106 kDa

Observed molecular weight:
106 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
MTHFD1L

Synonyms
dJ292B18.2, DKFZp586G1517, FLJ21145, FTHFSDC1, MTC1THFS, MTHFD1L
Background

MTHFD1L(Monofunctional C1-tetrahydrofolate synthase, mitochondrial) is also named as FTHFSDC1(Formyltetrahydrofolate synthetase). MTHFD1L enzyme is present in mitochondria from normal embryonic tissues and embryonic fibroblast cell lines, and embryonic mitochondria possess the ability to synthesize formate from glycine. It catalyzes the final step in the mitochondrial conversion of 1-C units to formate in embryos. Moreover, MTHFD1L levels were substantially higher in embryonic mitochondria than in adult liver mitochondria and embryonic mitochondria exhibited greater formate production(PMID:19948730). It has 2 isoforms produced by alternative splicing.


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