MUTYH Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 19650-1-AP

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Freight/Packing

Con: 42 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
HeLa cells, COLO 320 cells, Jurkat cells, K-562 cells, mouse thymus tissue, Raji cells

Positive IP detected in:
HeLa cells

Positive IHC detected in:
human kidney tissue, human colon cancer tissue, human kidney tissue

Recommended dilution:
WB : 1:500-1:3000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
mutY homolog (E. coli)

Calculated molecular weight:
60 kDa

Observed molecular weight:
53-64 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
MUTYH

Synonyms
hMYH, MutY homolog, mutY homolog (E. coli), MUTYH, MYH
Background

MUTYH(MutY homolog) is also named as MYH and belongs to the Nth/MutY family. The gene enconde an A/G-specific adenine DNA glycosylase that it is involved in oxidative DNA damage repair and initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities(PMID:10684930). Defects in MUTYH are a cause of familial adenomatous polyposis type 2 (FAP2) and gastric cancer (GASC). It has 6 isoforms produced by alternative splicing with the molecular weight between 57 kDa and 60 kDa.


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