MYCN Antibody 4 Publications

Rabbit Polyclonal| Catalog number: 10159-2-AP

Featured Product KD/KO validated

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Con: 52 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
SKOV-3 cells, C6 cells, human placenta tissue, mouse brain tissue, rat brain tissue, SH-SY5Y cells

Positive IHC detected in:
human thyroid cancer tissue

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)

Calculated molecular weight:
65 kDa

Observed molecular weight:
67 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
MYCN

Synonyms
bHLHe37, MODED, MYCN, N myc, N myc proto oncogene protein, ODED
Background

MYCN, also named as BHLHE37 and NMYC, is a transcription factor. It is primarily expressed in normal developing embryos and is thought to be critical in brain and other neural development. It is often amplified in human neuroblastomas. IR34A can suppress MYCN expression, it suggest MYCN has a role in cell growth. The expression of the MCYN is upregulated in a variety of human tumors, most frequently neuroblastoma, where the level of expression appears to increase as the tumor progresses.


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