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MYD88 Antibody 39 Publications

Rabbit Polyclonal| Catalog number: 23230-1-AP

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Con: 35 μg/150 μl

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Tested Applications

Applications:
WB, IHC, ELISA
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Images See all

MYD88 Antibody WB A549 cells 23230-1-AP

Various lysates were subjected to SDS PAGE followed by western blot with 23230-1-AP (MYD88 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours

MYD88 Antibody WB HepG2 cells 23230-1-AP

WB result of MYD88 antibody (23230-1-AP; 1:1000; incubated at room temperature for 1.5 hours) with sh-Control and sh-MYD88 transfected HepG2 cells

Species specificity:
human, African green monkey, sheep, swine
Positive WB detected in:
A549 cells, HepG2 cells, MCF-7 cells
Recommended dilution:
WB : 1:1000-1:4000
Sample-dependent, check data in Validation tab

Product Information

Source:
Rabbit
Purification method:
Antigen affinity purification
Isotype:
IgG
Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information

Immunogen:
MYD88 fusion protein Ag19770
Full name:
myeloid differentiation primary response gene (88)
Calculated molecular weight:
33 kDa
Observed molecular weight:
33 kDa
GenBank accession number:
BC013589
Gene ID (NCBI):
4615
Gene symbol
MYD88
Synonyms
MYD88, MYD88D

Background

Myeloid differentiation primary response 88 (MYD88) is an adapter protein critical to the innate and adaptive immune response.

 What is the molecular weight of MYD88?

The molecular weight of MYD88 is 33 kDa.

 What is the cellular localization of MYD88?

The subcellular localization of MYD88 is largely confined to the cytoplasm as condensed forms or aggregated structures.

 What is the role of MYD88 in the IL-1R signaling pathway?

MYD88 plays a major role in the inflammatory signaling pathways downstream of Toll-like receptor (TLR) and interleukin-1 receptor (IL-1R) families. MYD88 links these receptors to IL-1R-associated kinases (IRAK), such as IRAK1 and IRAK2, via protein–protein interactions. The C-terminal TIR domain of MYD88 mediates the interaction with the receptors, whereas the N-terminal death domain of MYD88 associates with IRAK family members (PMID: 25580251). MYD88 acts via its intermediate domain to phosphorylate and thus activate IRAK1, IRAK2, IRF7, and TRAF6 to trigger NF-kappa-B signaling and cytokine secretion as part of the inflammatory response (PMID: 19679662).

 What is MYD88's involvement in disease?

Defects in MYD88 due to deficiency of the protein leads to recurrent pyogenic bacterial infections, including invasive pneumococcal disease. Patients usually die between 1 and 11 months of age, but surviving patients are otherwise healthy with normal resistance to other microbes (PMID: 18669862). Mutations in the MYD88 gene also lead to the development of cancers such as lymphoma (PMID: 21179087) and some autoimmune disorders like ulcerative colitis (PMID: 24189845).



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