MYL3 Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 10913-1-AP

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Freight/Packing

Con: 45 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
mouse heart tissue, human heart tissue, mouse skeletal muscle tissue

Positive IP detected in:
mouse heart tissue

Positive IHC detected in:
human heart tissue,human lung cancer tissue, human skeletal muscle tissue

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:2000-1:14000 for WB
IHC : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
myosin, light chain 3, alkali; ventricular, skeletal, slow

Calculated molecular weight:
22 kDa

Observed molecular weight:
22-27 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
MYL3

Synonyms
Cardiac myosin light chain 1, CMH8, CMLC1, MLC1SB, MLC1V, MYL3, Myosin light chain 3, VLC1
Background

MYL3, also named as MLC1v, is an essential light chain of myosin that is associated with muscle contraction. It is expressed in ventricular and slow skeletal muscle. MYL3 may serve as a target for caspase-3 in dying cardiomyocytes. Mutations of MYL3 gene cause hypertrophic cardiomyopathy. MYL3 has been identified as potential serum biomarker for drug induced myotoxicity. Great increase in MYL3 serum concentration has been observed in rats with cardiac and skeletal muscle injury. (PMID:21685905)


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