Napsin A Monoclonal antibody

Napsin A Monoclonal Antibody for ELISA

Host / Isotype

Mouse / IgG1

Reactivity

human, rat , mouse

Applications

IHC, ELISA

Conjugate

Unconjugated

CloneNo.

2D12A2

Cat no : 60259-1-Ig

Synonyms

Asp 4, ASP4, Aspartyl protease 4, KAP, Kdap, NAP1, NAPA, NAPSA, Napsin 1, Napsin A, napsin A aspartic peptidase, Pronapsin A, SNAPA, TA01/TA02



Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Published Applications

IHCSee 1 publications below

Product Information

The immunogen of 60259-1-Ig is Napsin A Fusion Protein expressed in E. coli.

Tested Reactivity human, rat , mouse
Cited Reactivityhuman
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Immunogen Napsin A fusion protein Ag9721
Full Name napsin A aspartic peptidase
Calculated Molecular Weight 420 aa, 45 kDa
Observed Molecular Weight 45 kDa
GenBank Accession NumberBC017842
Gene Symbol NAPSA
Gene ID (NCBI) 9476
RRIDAB_2881380
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

Napsin is found in two isoforms, napsin A and B, with highly homologous nucleotide sequences (91.2%). Napsin A appears to be a functional proteinase, predominantly expressed in lung and kidney. Napsin B is transcribed exclusively in cells related to the immune system and lacks an in-frame stop codon and is believed to be a pseudogene.(PMID:12698189). Napsin A is superior to TTF-1 in distinguishing primary lung ACA from other carcinomas (except kidney), particularly primary lung small cell carcinoma, and primary thyroid carcinoma.(PMID:22288963).

Publications

SpeciesApplicationTitle
humanIHC

Oncotarget

Accelerated hepatocellular carcinoma development in CUL4B transgenic mice.

Authors - Jupeng Yuan