NIP7 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 16839-1-AP

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Freight/Packing

Con: 21 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
mouse liver tissue, HeLa cells, HepG2 cells

Positive IP detected in:
mouse liver tissue

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
nuclear import 7 homolog (S. cerevisiae)

Calculated molecular weight:
180aa,20 kDa

Observed molecular weight:
20,15kd

GenBank accession number:

Gene ID (NCBI):

Gene symbol
NIP7

Synonyms
CGI 37, FLJ10296, HSPC031, HSPC180, KD93, NIP7, OK/SW cl.76, OK/SW cl.78
Background

Nip7 was initially identified in yeast as required for processing of the 27S pre-rRNA to form the mature 25S and 5.8S rRNAs (PMID: 9891085). It localizes to the nucleolus but was also found to sediment in the region of free 60S subunits in sucrose density gradients (PMID: 9891085). Experimental evidence suggests that the P. abyssi Nip7 may be an exosome regulatory factor. It binds preferentially to U- and AU-rich RNAs and strongly inhibits the exosome due to its association with both the exosome complex and the substrate RNA.


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