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  • KD/KO Validated

NPTX2 Polyclonal antibody

NPTX2 Polyclonal Antibody for WB, IP, IHC, ELISA

Host / Isotype

Rabbit / IgG


human, mouse, rat





Cat no : 10889-1-AP


NARP, Neuronal pentraxin 2, neuronal pentraxin II, NPTX2

Tested Applications

Positive WB detected inmouse brain tissue, SH-SY5Y cells, PC-3 cells, rat brain tissue
Positive IP detected inmouse brain tissue
Positive IHC detected inhuman brain tissue, human pancreas cancer tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Recommended dilution

Western Blot (WB)WB : 1:1000-1:6000
Immunoprecipitation (IP)IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate
Immunohistochemistry (IHC)IHC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

10889-1-AP targets NPTX2 in WB, IP, IF, FC, IHC, CoIP, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Cited Reactivityhuman, mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen NPTX2 fusion protein Ag1326
Full Name neuronal pentraxin II
Calculated Molecular Weight 47 kDa
Observed Molecular Weight 47-50 kDa
GenBank Accession NumberBC009924
Gene Symbol NPTX2
Gene ID (NCBI) 4885
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

Neuronal pentraxins constitute a family of proteins that are homologous to C-reactive protein (CRP) and serum amyloid P component (SAP), including NPTX1, NPTX2, and the neuronal pentraxin receptor (NPTXR). NPTX2, also known as NARP (neuronal activity-regulated pentaxin), is a secreted protein involved in excitatory synapse formation. It also plays a role in the clustering of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors at established synapses, resulting in non-apoptotic cell death of dopaminergic nerve cells. NPTX2 is highly up-regulated in Parkinson's disease (PD), suggesting it may be involved in the pathology of PD. (PMID: 12895424; 17987278; 10748068)


Product Specific Protocols
WB protocol for NPTX2 antibody 10889-1-APDownload protocol
IHC protocol for NPTX2 antibody 10889-1-APDownload protocol
IP protocol for NPTX2 antibody 10889-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols



J Invest Dermatol

NPTX2 Promotes EMT in Cutaneous Squamous Cell Carcinoma via Mettl3-Mediated m6A Methylation of Snail

Authors - Tong Kang


NPTX2 is a key component in the regulation of anxiety.

Authors - Simon Chang
  • KO Validated

Front Immunol

Identification of Neuronal Pentraxins as Synaptic Binding Partners of C1q and the Involvement of NP1 in Synaptic Pruning in Adult Mice.

Authors - Réka Á Kovács

J Neurochem

Quantitative proteomic analysis of the frontal cortex in Alzheimer's disease.

Authors - Gajanan Sathe

J Cancer

Promoter Methylation-Mediated NPTX2 Silencing Promotes Tumor Growth in Human Prostate Cancer.

Authors - Yixi Su

Mol Biol Rep

The neuronal pentraxin II gene (NPTX2) inhibit proliferation and invasion of pancreatic cancer cells in vitro.

Authors - Zhang Ling L


The reviews below have been submitted by verified Proteintech customers who received an incentive forproviding their feedback.


Xin (Verified Customer) (10-10-2022)

Very good with WB to detect endogenous NPTX2 with a clean and clear band with the right MW.

  • Applications: Western Blot
  • Primary Antibody Dilution: 1:3000
  • Cell Tissue Type: mouse brain lysate
NPTX2 Antibody Western Blot validation (1:3000 dilution) in mouse brain lysate (Cat no:10889-1-AP)

Jerome (Verified Customer) (05-07-2019)

This protein should be in the secretory pathway but instead the antibody stains the nucleus

  • Applications: Immunofluorescence,
  • Primary Antibody Dilution: 100
  • Cell Tissue Type: Hela Cells
NPTX2 Antibody Immunofluorescence, validation (100 dilution) in Hela Cells (Cat no:10889-1-AP)