NUP98-NUP96 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 12329-1-AP

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Freight/Packing

Con: 40 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
COLO 320 cells, HeLa cells, Jurkat cells, K-562 cells, MCF-7 cells

Positive IP detected in:
COLO 320 cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
nucleoporin 98kDa

Calculated molecular weight:
98 kDa

Observed molecular weight:
98kd

GenBank accession number:

Gene ID (NCBI):

Gene symbol
NUP98

Synonyms
96 kDa nucleoporin, ADAR2, ADIR2, Nucleoporin Nup96, NUP196, NUP96, NUP98 NUP96, NUP98-NUP96
Background

Nup98-Nup96 (also known as Nup196, ADIR2 or ADAR2), encoded by NUP98 gene, is a component of the nuclear pore complex (NPC) . It is first synthesized as 186-198 kDa Nup98-Nup96 precursors and the precursors shortly undergo autoproteolysis to give rise to two nucleoporins, the amino-terminal Nup98 (Nup98-N) and carboxy-terminal Nup96 (Nup96-C). Both of Nup98 and Nup96 are localized to the nucleoplasmic side of the NPC. This antibody was raised against the carboxy-terminal region of Nup98-Nup96, it recognizes all Nup98-Nup96 proteins except Nup98-N. Since the autoproteolysis is very rapid this antibody usually detected 98-115 kDa Nup96 protein in multiple cell lines. It is notable that RNA-editing deaminase 1 (Gene ID: 104), also named ADAR2, is a different protein from Nup98-Nup96 (ADAR2).


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