OAS2 Antibody 2 Publications

Rabbit Polyclonal| Catalog number: 19279-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 50 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
Jurkat cells, HL-60 cells, human liver tissue, Jurkat cells, mouse lung tissue

Positive IP detected in:
Jurkat cells

Positive IHC detected in:
human breast cancer tissue, human breast cancer tissue, human colon tissue, human liver cancer tissue

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:20-1:200
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
2'-5'-oligoadenylate synthetase 2, 69/71kDa

Calculated molecular weight:
82 kDa

Observed molecular weight:
66-71 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
OAS2

Synonyms
(2 5)oligo(A) synthase 2, 2 5 oligoadenylate synthase 2, 2 5A synthase 2, OAS2, p69 OAS / p71 OAS, p69OAS / p71OAS
Background

The 2-prime,5-prime oligoadenylate synthetases (OASs), such as OAS2, are interferon-induced proteins characterized by their capacity to catalyze the synthesis of 2-prime,5-prime oligomers of adenosine (2-5As). OAS2 is also named as p69 OAS / p71 OAS. It has 3 isoforms(71/69/20 kDa) produced by alternative splicing. The OAS2 isozymes are 69–71 kDa and form dimers(PMID:17765707). Glycosylation is essential for its activity(PMID:9880569). Constitutive expression of the 69-kDa form of the OAS2 protein in human cells inhibited the replication of encephalomyocarditis virus (EMCV) but not that of VSV, Sendai virus, or reovirus(PMID:16501108). This antibody is specific to isoform p71 and isoform p69 of OAS2.


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