OGT Antibody 8 Publications

Rabbit Polyclonal| Catalog number: 11576-2-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 55 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
human brain tissue, human liver tissue, mouse brain tissue, mouse liver tissue, rat brain tissue

Positive IP detected in:
mouse brain tissue

Recommended dilution:
WB : 1:500-1:3000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)

Calculated molecular weight:
1046aa,117 kDa

Observed molecular weight:
110 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
OGT

Synonyms
HRNT1, O GLCNAC, OGT
Background

O-linked N-acetylglucosamine transferase (OGT) catalyzes the attachment of N-acetylglucosamine (GlcNAc) monosaccharides to the hydroxyl group of serine or threonine residues of numerous nuclear and cytoplasmic proteins and may play important roles in a large number of diverse intracellular processes ranging from translational control, transcription, transcriptional repression, insulin resistance and regulation of the cell cycle. It exists as a heterotrimeric complex with two 110 kDa and one 70 kDa subunits. Recent studies have shown that O-GlcNAcylation plays essential roles in cancer formation and progression. O-GlcNAcylation as well as OGT expression was found to be significantly elevated in the cancer tissues.


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