PAX3 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 21386-1-AP

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Freight/Packing

Con: 89 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
mouse skin tissue, HEK-293 cells

Positive IP detected in:
mouse skin tissue

Recommended dilution:
WB : 1:500-1:3000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
paired box 3

Calculated molecular weight:
484aa,53 kDa

Observed molecular weight:
56-60 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
PAX3

Synonyms
CDHS, HUP2, paired box 3, Paired box protein Pax 3, PAX3, WS1
Background

PAX3, a transcription factor and multifunctional regulatory protein, is normally expressed during embryonic development. In the nervous system, PAX3 is involved in neural tube closure, neural crest development, and peripheral neuron differentiation. In the present study, PAX3 was reported as a novel regulator of GFAP transcription, and the overexpression and suppression of PAX3 could inhibit and promote NSC differentiation, respectively. In muscle development, PAX3 ensures the survival of myogenic progenitor cells with Pax3-expressing progenitors giving rise to both skeletal and smooth muscle cells. PAX3 also has a well-established role in the development of melanocytes during embryogenesis, and has recently been characterized as a molecular switch in the mature melanocyte. Mutations in PAX3 can cause Waardenburg syndrome.


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