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Directed Differentiation of Human Induced Pluripotent Stem Cells into Fallopian Tube Epithelium.
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PAX8 is a member of the paired box (PAX) family of transcription factors, typically containing a paired box domain and a paired-type homeodomain. The specific function of the PAX8 is unknown but it may involve kidney cell differentiation, thyroid development, or thyroid dysgenesis. Several other splice variants have been proposed but the full nature of these products has not been described. Pax8 is also a marker of otic progenitor cells. PAX8 is a useful marker in distinguishing ovarian carcinomas from mammary carcinomas. PAX8 can be used in a differential diagnosis between primary and secondary ovarian carcinomas in patients with a previous history of breast cancer. Mutation of PAX8 will cause congenital hypothyroidism non-goitrous type 2 (CHNG2). This antibody is specific to Pax8.