PAX8 Polyclonal antibody

PAX8 Polyclonal Antibody for IF, WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, IF, ELISA

Conjugate

Unconjugated

Cat no : 21384-1-AP

Synonyms

paired box 8, Paired box protein Pax 8, PAX 8, PAX8



Tested Applications

Recommended dilution

ApplicationDilution
Sample-dependent, check data in validation data gallery

Published Applications

IFSee 1 publications below

Product Information

The immunogen of 21384-1-AP is PAX8 Fusion Protein expressed in E. coli.

Tested Reactivity human
Cited Reactivity human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen PAX8 fusion protein Ag16019
Full Name paired box 8
Calculated molecular weight 450 aa, 48 kDa
GenBank accession numberBC001060
Gene symbol PAX8
Gene ID (NCBI) 7849
Conjugate Unconjugated
Form Liquid
Purification Method Antigen affinity purification
Storage Buffer PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

PAX8 is a member of the paired box (PAX) family of transcription factors, typically containing a paired box domain and a paired-type homeodomain. The specific function of the PAX8 is unknown but it may involve kidney cell differentiation, thyroid development, or thyroid dysgenesis. Several other splice variants have been proposed but the full nature of these products has not been described. Pax8 is also a marker of otic progenitor cells. PAX8 is a useful marker in distinguishing ovarian carcinomas from mammary carcinomas. PAX8 can be used in a differential diagnosis between primary and secondary ovarian carcinomas in patients with a previous history of breast cancer. Mutation of PAX8 will cause congenital hypothyroidism non-goitrous type 2 (CHNG2). This antibody is specific to Pax8.

Publications

SpeciesApplicationTitle
humanIF

Sci Rep

Directed Differentiation of Human Induced Pluripotent Stem Cells into Fallopian Tube Epithelium.

Authors - Nur Yucer