PDE5A Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 22624-1-AP

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Freight/Packing

Con: 34 μg/150 μl

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Species specificity:
human, mouse, rabbit

Positive WB detected in:
SKOV-3 cells, NIH/3T3 cells, SKOV-3 cells

Positive IP detected in:
SKOV-3 cells

Positive IHC detected in:
human ovary tumor tissue

Positive IF detected in:
SKOV-3 cells

Recommended dilution:
WB : 1:200-1:1000
IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB
IHC : 1:50-1:500
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen Affinity purified

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
phosphodiesterase 5A, cGMP-specific

Calculated molecular weight:
875aa,100 kDa

Observed molecular weight:
100 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
PDE5A

Synonyms
CGB PDE, CN5A, PDE5, PDE5A, PDE5A1, phosphodiesterase 5A, cGMP
Background

PDE5A (cGMP-binding cGMP-specific phosphodiesterase) plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP. Through alternative splicing, the PDE5A gene produces three proteins (PDE5A1, PDE5A2, and PDE5A3) that differ in their N termini and range in mass from 89 to 105 kDa. (PMID: 25704994; 21215707). A second 70 kDa band was consistently observed in heart tissue that either reflected a splice variant or proteolytic fragment of PDE5A. (PMID: 15576651).


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