PDE6B Antibody 2 Publications

Rabbit Polyclonal| Catalog number: 22063-1-AP

  • Print page
  • Download PDF

-_-

Freight/Packing

Con: 63 μg/150 μl

Choose size:

Please visit your regions distributor:


Species specificity:
human, mouse

Positive WB detected in:
mouse eye tissue, A549 cells

Positive IP detected in:
Y79 cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
phosphodiesterase 6B, cGMP-specific, rod, beta

Calculated molecular weight:
854aa,98 kDa

Observed molecular weight:
98 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
PDE6B

Synonyms
CSNB3, GMP PDE beta, PDE6B, PDEB, rd1, RP40
Background

PDE6 is a cGMP-specific PDE family and presents multicomponent enzyme complexes. The rod PDE6 enzyme is comprised of two catalytic subunits, PDE6A and PDE6B and it is expressed in human lungs(PMID:20979602). PDE6B(Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta) is also named as PDEB and belongs to the cyclic nucleotide phosphodiesterase family. PDE6B also has a C-terminal CAAX motif for posttranslational processing involving lipidation, proteolysis, and carboxymethylation(PMID:8394243). Defects in PDE6B are the cause of retinitis pigmentosa type 40 (RP40)(PMID:22334370) and congenital stationary night blindness autosomal dominant type 2 (CSNBAD2)(PMID:8075643).


Back
to top