Podoplanin Antibody 3 Publications

Rabbit Polyclonal| Catalog number: 11629-1-AP

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Con: 45 μg/150 μl

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Species specificity:
human

Positive WB detected in:
HEK-293 cells, Transfected HEK-293 cells

Positive IHC detected in:
human colon cancer tissue, human colon cancer tissue, human lung tissue, human skeletal muscle tissue

Positive FC detected in:
HUVEC cells

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
podoplanin

Calculated molecular weight:
17 kDa, 25 kDa

Observed molecular weight:
43 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
PDPN

Synonyms
AGGRUS, D2 40, D2 40,M2A, Glycoprotein 36, GP36, Gp38, GP40, HT1A 1, M2A, OTS8, PA2.26, PA2.26 antigen, PDPN, podoplanin, PSEC0025, T1 alpha, T1A, T1A 2
Background

M2A(D2-40) antigen is a previously identified marker for CIS and seminoma. M2A (D2-40) antigen has been identical to PDPN.(PMID: 16736189). PDPN, also named as GP36, Gp38, GP40, HT1A-1, OTS8, PA2.26, T1A and T1A-2, has a function in developing testis, most likely at the level of cell-cell interactions among pre-meiotic germ cells and immature Sertoli cells. It may be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, PDPN induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. It is required for normal lung cell proliferation and alveolus formation at birth. PDPN induces platelet aggregation. It does not have any effect on folic acid or amino acid transport and does not function as a water channel or as a regulator of aquaporin-type water channels. The antibody is specific to Podoplanin.


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