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Placental Growth Factor Polyclonal antibody
Placental Growth Factor Polyclonal Antibody for IHC, WB, ELISA
Host / Isotype
Rabbit / IgG
Reactivity
human and More (2)
Applications
WB, IHC, IF, ELISA
Conjugate
Unconjugated
Cat no : 10642-1-AP
Synonyms
Validation Data Gallery
Tested Applications
Positive WB detected in | human placenta tissue |
Positive IHC detected in | human placenta tissue, human breast cancer tissue, human meningioma tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
Recommended dilution
Application | Dilution |
---|---|
Western Blot (WB) | WB : 1:200-1:600 |
Immunohistochemistry (IHC) | IHC : 1:200-1:800 |
Sample-dependent, check data in validation data gallery |
Published Applications
KD/KO | See 2 publications below |
WB | See 6 publications below |
IHC | See 3 publications below |
IF | See 4 publications below |
Product Information
10642-1-AP targets Placental Growth Factor in WB, IHC, IF, ELISA applications and shows reactivity with human samples.
Tested Reactivity | human |
Cited Reactivity | human, mouse, rat |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | Placental Growth Factor fusion protein Ag0969 |
Full Name | placental growth factor |
Calculated molecular weight | 25 kDa |
Observed molecular weight | 50 kDa |
GenBank accession number | BC007789 |
Gene symbol | PGF |
Gene ID (NCBI) | 5228 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Antigen affinity purification |
Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
Background Information
Placenta growth factor (PLGF) is a homodimeric glycoprotein, 46-50 kDa in size, belonging to the vascular endothelial growth factor (VEGF) sub-family. It plays an important role in pathological VEGF-driven angiogenesis. PLGF is expressed not only in placental cells but also in colon and mammary carcinomas. It acts as a primary inflammatory instigator of atherosclerotic plaque instability and thus may be useful as a risk-predicting biomarker in patients with acute coronary syndromes (ACS).
Protocols
Product Specific Protocols | |
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WB protocol for Placental Growth Factor antibody 10642-1-AP | Download protocol |
IHC protocol for Placental Growth Factor antibody 10642-1-AP | Download protocol |
Standard Protocols | |
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Click here to view our Standard Protocols |
Publications
Species | Application | Title |
---|---|---|
J Assist Reprod Genet The role and mechanism of asymmetric dimethylarginine in fetal growth restriction via interference with endothelial function and angiogenesis. | ||
Reproduction Decreased PGF May Contribute to Trophoblast Dysfunction in Fetal Growth Restriction. | ||
Eur J Pharmacol PlGF signaling and macrophage repolarization contribute to the anti-neoplastic effect of metformin.
| ||
Placenta MiR-124-3p promotes trophoblast cell HTR-8/SVneo pyroptosis by targeting placental growth factor. | ||
Cancer Sci The PLGF/c-MYC/miR-19a axis promotes metastasis and stemness in gallbladder cancer. | ||
J Cell Mol Med Complement 5a-mediated trophoblasts dysfunction is involved in the development of pre-eclampsia. |