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Placental Growth Factor Antibody
Placental Growth Factor Polyclonal Antibody for IHC, WB, ELISA
Host / Isotype
Rabbit / IgG
Reactivity
human and More (2)
Applications
WB, IHC, IF, ELISA
Conjugate
Unconjugated
Cat no : 10642-1-AP
Synonyms
D12S1900, PGF, PGFL, PIGF, Placenta growth factor, placental growth factor, PLGF, PlGF 2, SHGC 10760
Validation Data Gallery
Tested Applications
| Positive WB detected in | human placenta tissue |
| Positive IHC detected in | human placenta tissue, human breast cancer tissue, human meningioma tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
Recommended dilution
| Application | Dilution |
|---|---|
| Western Blot (WB) | WB : 1:200-1:600 |
| Immunohistochemistry (IHC) | IHC : 1:200-1:800 |
| Sample-dependent, check data in validation data gallery | |
Published Applications
| KD/KO | See 2 publications below |
| WB | See 5 publications below |
| IHC | See 1 publications below |
| IF | See 3 publications below |
Product Information
10642-1-AP targets Placental Growth Factor in WB, IHC, IF, ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Cited Reactivity | human, mouse, rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Placental Growth Factor fusion protein Ag0969 |
| Full Name | placental growth factor |
| Calculated molecular weight | 25 kDa |
| Observed molecular weight | 50 kDa |
| GenBank accession number | BC007789 |
| Gene symbol | PGF |
| Gene ID (NCBI) | 5228 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| Storage Buffer | PBS with 0.1% sodium azide and 50% glycerol pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
Background Information
Placenta growth factor (PLGF) is a homodimeric glycoprotein, 46-50 kDa in size, belonging to the vascular endothelial growth factor (VEGF) sub-family. It plays an important role in pathological VEGF-driven angiogenesis. PLGF is expressed not only in placental cells but also in colon and mammary carcinomas. It acts as a primary inflammatory instigator of atherosclerotic plaque instability and thus may be useful as a risk-predicting biomarker in patients with acute coronary syndromes (ACS).
Protocols
| Product Specific Protocols | |
|---|---|
| WB protocol for Placental Growth Factor antibody 10642-1-AP | Download protocol |
| IHC protocol for Placental Growth Factor antibody 10642-1-AP | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
Publications
| Species | Application | Title |
|---|---|---|
J Assist Reprod Genet The role and mechanism of asymmetric dimethylarginine in fetal growth restriction via interference with endothelial function and angiogenesis. | ||
Reproduction Decreased PGF May Contribute to Trophoblast Dysfunction in Fetal Growth Restriction. | ||
Eur J Pharmacol PlGF signaling and macrophage repolarization contribute to the anti-neoplastic effect of metformin.
| ||
Cancer Sci The PLGF/c-MYC/miR-19a axis promotes metastasis and stemness in gallbladder cancer. | ||
J Cell Mol Med Complement 5a-mediated trophoblasts dysfunction is involved in the development of pre-eclampsia. | ||
Biomaterials Combination antitumor immunotherapy with VEGF and PIGF siRNA via systemic delivery of multi-functionalized nanoparticles to tumor-associated macrophages and breast cancer cells.
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