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- KD/KO Validated
Placental Growth Factor Antibody
Placental Growth Factor Polyclonal Antibody for IHC, WB, ELISA
Cat no : 10642-1-AP
D12S1900, PGF, PGFL, PIGF, Placenta growth factor, placental growth factor, PLGF, PlGF 2, SHGC 10760
|Positive WB detected in||human placenta tissue|
|Positive IHC detected in||human placenta tissue, human breast cancer tissue, human meningioma tissue|
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
|Western Blot (WB)||WB : 1:200-1:600|
|Immunohistochemistry (IHC)||IHC : 1:200-1:800|
|Sample-dependent, check data in validation data gallery|
10642-1-AP targets Placental Growth Factor in WB, IHC, IF, ELISA applications and shows reactivity with human samples.
|Cited Reactivity||human, mouse, rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Placental Growth Factor fusion protein Ag0969|
|Full Name||placental growth factor|
|Calculated molecular weight||25 kDa|
|Observed molecular weight||50 kDa|
|GenBank accession number||BC007789|
|Gene ID (NCBI)||5228|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.1% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
Placenta growth factor (PLGF) is a homodimeric glycoprotein, 46-50 kDa in size, belonging to the vascular endothelial growth factor (VEGF) sub-family. It plays an important role in pathological VEGF-driven angiogenesis. PLGF is expressed not only in placental cells but also in colon and mammary carcinomas. It acts as a primary inflammatory instigator of atherosclerotic plaque instability and thus may be useful as a risk-predicting biomarker in patients with acute coronary syndromes (ACS).
J Assist Reprod Genet
The role and mechanism of asymmetric dimethylarginine in fetal growth restriction via interference with endothelial function and angiogenesis.
Decreased PGF May Contribute to Trophoblast Dysfunction in Fetal Growth Restriction.
Eur J Pharmacol
PlGF signaling and macrophage repolarization contribute to the anti-neoplastic effect of metformin.
The PLGF/c-MYC/miR-19a axis promotes metastasis and stemness in gallbladder cancer.
J Cell Mol Med
Complement 5a-mediated trophoblasts dysfunction is involved in the development of pre-eclampsia.
Combination antitumor immunotherapy with VEGF and PIGF siRNA via systemic delivery of multi-functionalized nanoparticles to tumor-associated macrophages and breast cancer cells.