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Placental Growth Factor Polyclonal antibody

Placental Growth Factor Polyclonal Antibody for IHC, WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human and More (2)

Applications

WB, IHC, IF, ELISA

Conjugate

Unconjugated

Cat no : 10642-1-AP

Synonyms

D12S1900, PGF, PGFL, PIGF, Placenta growth factor, placental growth factor, PLGF, PlGF 2, SHGC 10760



Tested Applications

Positive WB detected inhuman placenta tissue
Positive IHC detected inhuman placenta tissue, human breast cancer tissue, human meningioma tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:200-1:600
Immunohistochemistry (IHC)IHC : 1:200-1:800
Sample-dependent, check data in validation data gallery

Product Information

10642-1-AP targets Placental Growth Factor in WB, IHC, IF, ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Cited Reactivity human, mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen Placental Growth Factor fusion protein Ag0969
Full Name placental growth factor
Calculated molecular weight 25 kDa
Observed molecular weight 50 kDa
GenBank accession numberBC007789
Gene symbol PGF
Gene ID (NCBI) 5228
Conjugate Unconjugated
Form Liquid
Purification Method Antigen affinity purification
Storage Buffer PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

Placenta growth factor (PLGF) is a homodimeric glycoprotein, 46-50 kDa in size, belonging to the vascular endothelial growth factor (VEGF) sub-family. It plays an important role in pathological VEGF-driven angiogenesis. PLGF is expressed not only in placental cells but also in colon and mammary carcinomas. It acts as a primary inflammatory instigator of atherosclerotic plaque instability and thus may be useful as a risk-predicting biomarker in patients with acute coronary syndromes (ACS).

Protocols

Product Specific Protocols
WB protocol for Placental Growth Factor antibody 10642-1-APDownload protocol
IHC protocol for Placental Growth Factor antibody 10642-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
humanWB

J Assist Reprod Genet

The role and mechanism of asymmetric dimethylarginine in fetal growth restriction via interference with endothelial function and angiogenesis.

Authors - Yan Dai
humanIHC

Reproduction

Decreased PGF May Contribute to Trophoblast Dysfunction in Fetal Growth Restriction.

Authors - Weibin Wu
human,mouseIF,WB

Eur J Pharmacol

PlGF signaling and macrophage repolarization contribute to the anti-neoplastic effect of metformin.

Authors - Qiang Ma
  • KD Validated
humanWB

Placenta

MiR-124-3p promotes trophoblast cell HTR-8/SVneo pyroptosis by targeting placental growth factor.

Authors - Jun Tao
humanWB

Cancer Sci

The PLGF/c-MYC/miR-19a axis promotes metastasis and stemness in gallbladder cancer.

Authors - Huaifeng Li
human,mouseWB,IF

J Cell Mol Med

Complement 5a-mediated trophoblasts dysfunction is involved in the development of pre-eclampsia.

Authors - Yu Ma